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HC Technology
Propylparaben
Categories:
Pharmaceutical Excipients

Propylparaben

Alias
Propyl p-hydroxybenzoate / Propyl 4-hydroxybenzoate / 4-Hydroxybenzoic acid propyl ester / Nipasol / Propylparaben (pharmacopoeia)
CAS No.
Molecular Formula
C10H12O3
Structure
Propylparaben Chemical Structure
Product Details

Product Overview

Usage

Used as an antimicrobial preservative in pharmaceutical excipients. Antimicrobial activity increases with carbon chain length, providing superior inhibition of molds and yeasts compared to methylparaben and ethylparaben. Widely applied in oral liquid preparations, topical ointments, creams, gels and suppositories. Often combined with methylparaben at different ratios (e.g., methylparaben:propylparaben = 4:1) to balance water solubility and antimicrobial efficacy. Also used for preservation in eye drops, syrups and other liquid formulations.
Specifications

Technical Specifications

Appearance White or off-white crystals or crystalline powder
Content (on dried basis) 98.0%–102.0%
Melting point 96–99℃
Acidity Compliant (0.1 mol/L NaOH consumption ≤0.1 mL)
Solution clarity and color Clear and colorless
Chloride (Cl) ≤0.035%
Sulfate (as SO₄) ≤0.024%
Related substances Individual impurity ≤0.4%, total impurities ≤0.8%
Loss on drying ≤0.5% (silica gel desiccator, vacuum dried to constant weight)
Residue on ignition ≤0.1%
Heavy metals ≤20 ppm
Arsenic ≤0.0002%
Logistics

Packaging, Storage & Transport

Packaging

25 kg fiber drum, double polyethylene liner

Storage

Store tightly closed in a cool, dry, well-ventilated place

Transport

Transport as general chemicals; protect from moisture, sunlight and physical damage; keep packaging intact